I-Andrographolide

I-Andrographolide iwumkhiqizo we-botanical okhishwe esitshalweni esenzeka ngokwemvelo e-China.Lesi sitshalo sinomlando obanzi wokusetshenziswa ku-TCM ekwelapheni izifo zepheshana eliphezulu lokuphefumula nezinye izifo ezivuthayo nezithathelwanayo.I-Andrographis paniculata yethulwa futhi yatshalwa e-Guangdong naseningizimu ye-Fujian ngeminyaka yama-50s.Isetshenziselwa ukwelapha izifo ezihlukahlukene ezithathelwanayo kanye nokulunywa yizinyoka.Eminyakeni yamuva nje, ukulima, ukwakheka kwamakhemikhali, i-pharmacology kanye nezici zomtholampilo ze-Andrographis paniculata ziye zafundwa eChina.I-Andrographis paniculata umuthi wendabuko waseShayina osetshenziswa kakhulu, onemiphumela yokususa ukushisa nobuthi, ukupholisa igazi kanye ne-detumescence.Ngokomtholampilo, isetshenziswa kakhulu ekwelapheni ukutheleleka kwepheshana lokuphefumula, i-acute bacillary dysentery, i-gastroenteritis, amakhaza, imfiva kanye nomfutho wegazi ophakeme.Ngokukhula kokusetshenziswa kabi kwama-antibiotic kanye nokusabela okubi, izwi lokuthuthukisa umuthi wendabuko waseShayina ngomphumela omuhle we-antibacterial liyakhula.I-Andrographis paniculata, njengomuthi wendabuko waseShayina onomphumela wokulwa namagciwane, iye yanakwa kakhulu yimboni yezemithi.

Ukukhishwa kwesitshalo se-Andrographis paniculata kwaziwa ukuthi kunemisebenzi eyahlukene yezokwelapha.I-Andrographolide, ingxenye enkulu ye-extract ibandakanyeka emsebenzini wayo wezokwelapha.Sifunde izinqubo zamaselula kanye nezinhloso ezilungiswe ukwelashwa kwe-andrographolide kumdlavuza womuntu namaseli omzimba.Ukwelashwa kwe-Andrographolide kuvimbe ukwanda kwe-in vitro kwemigqa yamaseli e-tumor ehlukene, emele izinhlobo ezahlukahlukene zomdlavuza.Ikhompiyutha yenza umsebenzi oqondile wokulwa nomdlavuza kumaseli omdlavuza ngokuboshwa komjikelezo weseli esigabeni se-G0/G1 ngokungeniswa kweprotheni evimbela umjikelezo weseli p27 kanye nokuncipha kokubonakaliswa kwe-cyclin-dependent kinase 4 (CDK4).Umsebenzi we-immunostimulatory we-andrographolide uboniswa ukwanda kokwanda kwama-lymphocyte nokukhiqizwa kwe-interleukin-2.I-Andrographolide iphinde yathuthukisa ukukhiqizwa kwe-tumor necrosis factor-alpha kanye ne-CD marker expression, okuholela ekwandeni komsebenzi we-cytotoxic wama-lymphocyte ngokumelene namaseli omdlavuza, okungase kube nomthelela emsebenzini wawo ongaqondile wokulwa nomdlavuza.Umsebenzi we-in vivo wokulwa nomdlavuza wenhlanganisela uphinde uqinisekiswe ngokumelene ne-B16F0 melanoma syngenic kanye namamodeli e-HT-29 e-xenograft.Le miphumela iphakamisa ukuthi i-andrographolide iyi-pharmacophore ethakazelisayo ene-anticancer kanye nemisebenzi ye-immunomodulatory ngakho-ke inamandla okuthuthukiswa njenge-ejenti yokwelapha umdlavuza.