Ngo-1931, Kungokokuqala ngqa ukuhlukanisa nokukhipha kubhontshisi wesoya.
Ngo-1962, Kungokokuqala ngqa ukuqinisekisa ukuthi iyafana ne-estrogen encelisayo.
Ngo-1986, ososayensi baseMelika bathola ama-isoflavone kubhontshisi wesoya avimbela amangqamuzana omdlavuza.
Ngo-1990, i-National Cancer Institute yase-United States yaqinisekisa ukuthi i-soy isoflavones yizinto zemvelo ezihamba phambili.
Phakathi neminyaka yawo-1990 ngasekupheleni, Isetshenziswa kabanzi emithini yabantu, ukunakekelwa kwezempilo, ukudla nokunye.
Ngo-1996, i-Us Food and Drug Administration (FDA) igunyaza ama-soy isoflavones njengokudla kwezempilo.
Ngo-1999, i-Us Food and Drug Administration (FDA) yagunyaza ukudla okusebenzayo kwe-soy isoflavones ukungena emakethe yase-US.
Kusukela ngo-1996, imikhiqizo yokudla yezempilo engaphezu kuka-40 equkethe isoflavone yesoya ivunyelwe eChina.
Singahlinzeka ngokucaciswa okuhlukile kwe-soy isoflavones ngokuya ngezidingo zekhasimende.
1.Soy isoflavones 5%-90%
I-5% isoflavones ye-Soy isetshenziswa kabanzi emkhakheni wokuphakelayo, ama-Flavonoid anemisebenzi ecacile yezinto eziphilayo ezilwaneni, ezingakhuthaza kakhulu ukukhula kwezilwane, ukunciphisa ukufakwa kwamafutha esiswini, ukuthuthukisa ukusebenza kokuzala kanye nokuthuthukisa ukungatheleleki.
Umthethonqubo wokukhula kwemfuyo yesilisa nezinkukhu
Imiphumela yabonisa ukuthi ukukhula kwemiqhele kwanda ngokushesha, isisindo sansuku zonke sanda ngo-10%, isisindo sesifuba nemisipha yemilenze sanda ngo-6.5% no-7.26% ngokulandelana, futhi izinga lokusebenzisa ukudla liyancipha kakhulu.Okuqukethwe kwe-DNA ngegramu ngayinye yemisipha yesifuba kwehle ngo-8.7% uma kuqhathaniswa neqembu elilawulayo, kodwa alukho ushintsho olubalulekile ku-DNA ephelele ye-pectoralis, nenani eliphelele le-RNA lenyuke ngo-16.5%, izinga le-serum urea lehla ngo-14.2%, ukusetshenziswa kwamaprotheni. izinga lenyuke kakhulu, kodwa alibanga namphumela obalulekile kuma-broilers wesifazane.Imiphumela yabonisa ukuthi amazinga e-testosterone, β - endorphin, i-hormone yokukhula, i-insulin-like growth factor-1, T3, T4 kanye ne-insulin athuthuke kakhulu.Imiphumela efanayo yatholwa ekuhlolweni kwedada le-Gaoyou wesilisa, ngokuzuza kwesisindo sansuku zonke kukhuphuke ngo-16.92%, izinga lokusebenzisa okuphakelayo lenyuke ngo-7.26%.Ingqikithi yezinga le-hormone yokukhula ku-serum lenyuke ngo-37.52% ngokungeza ama-500mg/kg we-soy isoflavones ekudleni kwezingulube, futhi ukugcwala kwe-urea nitrogen ne-cholesterol yama-metabolites kwehle kakhulu.
Umthelela ekusebenzeni kokukhiqiza kwezinkukhu zokubeka
Imiphumela yabonisa ukuthi inani elifanele le-daidzein (3-6mg / kg) lingandisa isikhathi sokubeka, ukwandisa izinga lokubeka, isisindo seqanda kanye nezinga lokuguqulwa kokudla.Ukwengeza i-daidzein engu-6mg/kg ekudleni kwezigwaca ezinezinyanga eziyi-12 ubudala kungakhuphula izinga lokubeka ngo-10.3% (P0.01).Ukwengeza i-daidzein engu-3mg/kg ekudleni kwamadada abekela amaqanda e-Shaoxing kungase kwenyuse izinga lokubeka ngo-13.13% kanye nezinga lokuguqulwa kokuphakelayo ngo-9.40%.Ucwaningo lwebhayoloji yamangqamuzana luye lwafakazela ukuthi isoflavone yesoya ingakhuthaza kakhulu ukubonakaliswa kofuzo lwe-GH kanye nokuqukethwe kwe-GH ezinkukhuni, ukuze kuthuthukiswe ukuzala.
Umphumela we-Daidzein ezingulubeni ezikhulelwe
Nakuba ukukhiqizwa kwezingulube zendabuko kufaka ukubaluleka kokuphakelwa kwangemva kokubeletha, ayinazo izindlela zokulawula ukukhula kwezingulube ngezingulube.Ngokulawulwa kwe-neuroendocrine kamama, ukushintsha ukukhiqizwa kwezakhi, ukukhuthaza ukukhula kwengane kanye nokwenza ngcono ikhwalithi kanye nenani lokuncelisa kuyisixhumanisi esibalulekile sokuthuthukisa ukusebenza kahle kokukhiqizwa kwengulube.Imiphumela yabonisa ukuthi ngemva kokuba izingulube ezikhulelwe zondliwa nge-daidzein, izinga le-insulin ye-plasma lehla futhi izinga le-IGF landa.Ukumunyisa kwezingulube ngosuku lwe-10 no-20 kwaba ngu-10.57% kanye no-14.67% ngaphezu kwalokho kweqembu elilawulayo, ngokulandelanayo.Uma kuqhathaniswa neqembu lokulawula, okuqukethwe kwe-GH, IGF, TSH kanye ne-PRL ku-colostrum kwanda kakhulu, kodwa okuqukethwe kwe-egg white matter kwakungekho ushintsho oluphawulekayo.Ukwengeza, izinga le-antibody kamama ku-colostrum liyenyuka futhi izinga lokusinda kwezingulube lenyuka.
I-soy isoflavones ingasebenza ngokuqondile kuma-lymphocyte futhi ikhuthaze ikhono lokuguqula i-lymphocyte elenziwa yi-PHA ngama-210%.I-isoflavones ye-soy ingathuthukisa ngokuphawulekayo wonke umsebenzi wokuzivikela komzimba kanye nomsebenzi wokuzivikela omzimba wezitho zebele.I-anti classical swine fever antibody egazini lengulube engulube ikhulelwe eqenjini lokuhlola inyuke ngo-41%, futhi leyo ku-colostrum inyuke ngo-44%.
Imithelela kuma-ruminants
Imiphumela yabonisa ukuthi i-soy isoflavones ingaba nomthelela ngokuqondile emisebenzini yama-enzymes okugaya ayinhloko we-rumen microorganisms futhi ithuthukise umsebenzi wabo wokugaya ukudla.Ku-vivo, ukwelashwa kwe-soy isoflavones kwenyusa kakhulu izinga le-testosterone lezinyathi zesilisa nezimvu, kwenyusa iphrotheni ye-rumen microbial kanye namazinga e-asidi yamafutha aguquguqukayo, futhi kwathuthukisa ukukhula namandla okukhiqiza ezilwane ezelusayo.
Ithonya ezilwaneni ezisencane
Esikhathini esedlule, ukuzalaniswa kwezilwane ezincane ngokuvamile kwaqala ngemva kokuzalwa, kodwa ngokombono, kwase kwephuze kakhulu.Ukuhlolwa kwabonisa ukuthi ukwelashwa kwezingulube ezikhulelwe nge-soy isoflavones akugcini nje ukwandisa ukuncelisa, kodwa futhi kwandise amasosha omzimba kamama obisini.Ukukhula kwezingulube ze-colostrum kukhuphuke ngo-11%, kanti izinga lokusinda kwezingulube zezinsuku ezingu-20 likhuphuke ngo-7.25% (96.2% vs 89.7%);ukuzuza kwansuku zonke, okuqukethwe kwe-testosterone kanye ne-calcium egazini kwezingulube zesilisa elunyuliwe kukhuphuke ngo-59.15%, 18.41% no-17.92%, ngokulandelana, kuyilapho amaphuphu ezingulube ezinsikazi elunyuliwe akhuphuke ngo-5 mg / kg isoflavones yesoya 39%, - 6. 86%, 6 47%.Lokhu kuvula indlela entsha yokuzalanisa izingulube.
I-Aglycon Soy Isoflavones
Ama-isoflavone e-soy kubhontshisi wesoya nokudla kukabhontshisi wesoya atholakala ikakhulukazi ngesimo se-glycoside, engamuncwe kalula ngumzimba womuntu.Uma kuqhathaniswa nama-isoflavone e-glucoside, ama-isoflavone e-soya yamahhala anomsebenzi ophezulu ngoba angamuncwa umzimba womuntu ngokuqondile.Kuze kube manje, ama-isoflavone angu-9 kanye nama-glucoside amathathu ahambisanayo (okungukuthi ama-isoflavone amahhala, abuye aziwe ngokuthi ama-glucosides) asehlukanisiwe kubhontshisi wesoya.
Ama-Isoflavone awuhlobo lwama-metabolites esibili akhiwe ekukhuleni kukabhontshisi wesoya, ikakhulukazi emagciwaneni kanye nasekudleni kukabhontshisi wembewu yesoya.Ama-Isoflavone ahlanganisa i-daidzein, ubhontshisi wesoya i-glycoside, i-genistein, i-genistein, i-daidzein, nobhontshisi wesoya.Ama-isoflavone emvelo ngokuvamile asesimweni se-β – glucoside, engafakwa nge-hydrolyzed ibe ama-isoflavone amahhala ngaphansi kwesenzo se-isoflavones ehlukahlukene ye-glucosidase.7, i-Daidzein (i-daidzein, eyaziwa nangokuthi i-daidzein) ingenye yezinto eziphambili ze-bioactive kuma-isoflavone kabhontshisi wesoya.Kuyaqapheleka ukuthi inemisebenzi eminingi ye-physiological emzimbeni womuntu.Ukumuncwa kwe-Daidzein emzimbeni womuntu ngokuyinhloko kuvela ezindleleni ezimbili: i-liposoluble glycosides ingamuncwa ngokuqondile emathunjini amancane;ama-glycosides asesimweni se-glycosides awakwazi ukudlula odongeni lwamathumbu amancane, kodwa awakwazi ukumuncwa ngodonga lwamathumbu amancane I-hydrolyzed yi-glucosidase kukholoni ukuze ikhiqize i-glycoside futhi imuncwa amathumbu.Imiphumela yokuhlolwa kwabantu ibonise ukuthi isoflavone yesoya yamuncwa kakhulu emathunjini, futhi izinga lokumunca laliyi-10-40%.I-soy isoflavones yamuncwa yi-microvilli, futhi ingxenye encane yafakwa emgodini wamathumbu nge-bile, futhi yabamba iqhaza ekujikelezeni kwesibindi ne-bile.Eziningi zazo zonakaliswe futhi zenziwa ama-microorganisms emathunjini nge-heterocyclic lysis, futhi imikhiqizo ingangena egazini.Ama-isoflavones e-metabolized akhishwa ngomchamo.
Ama-isoflavone e-soy atholakala ikakhulukazi ngendlela yama-glucosides, kuyilapho ukumuncwa kanye ne-metabolism ye-soy isoflavones emzimbeni womuntu kwenziwa ngendlela yama-soy isoflavones yamahhala.Ngakho-ke, ama-isoflavone amahhala nawo anegama elithi "i-soy isoflavones esebenzayo".
I-Soy isoflavone encibilikayo emanzini 10%
Isikhathi sokuthumela: Apr-02-2021
